Proteomic analysis of Intercept-treated platelets.
Identifieur interne : 000829 ( Main/Exploration ); précédent : 000828; suivant : 000830Proteomic analysis of Intercept-treated platelets.
Auteurs : Michel Prudent [Suisse] ; David Crettaz ; Julien Delobel ; Jean-Daniel Tissot ; Niels LionSource :
- Journal of proteomics [ 1876-7737 ] ; 2012.
Descripteurs français
- KwdFr :
- Buffy coat (cytologie), Buffy coat (microbiologie), Buffy coat (métabolisme), Femelle (MeSH), Furocoumarines (pharmacologie), Humains (MeSH), Mâle (MeSH), Photosensibilisants (pharmacologie), Plaquettes (cytologie), Plaquettes (microbiologie), Plaquettes (métabolisme), Protéines du sang (métabolisme), Protéome (métabolisme), Protéomique (MeSH), Stérilisation (méthodes), Viabilité microbienne (effets des médicaments et des substances chimiques).
- MESH :
- cytologie : Buffy coat, Plaquettes.
- effets des médicaments et des substances chimiques : Viabilité microbienne.
- microbiologie : Buffy coat, Plaquettes.
- métabolisme : Buffy coat, Plaquettes, Protéines du sang, Protéome.
- méthodes : Stérilisation.
- pharmacologie : Furocoumarines, Photosensibilisants.
- Femelle, Humains, Mâle, Protéomique.
English descriptors
- KwdEn :
- Blood Buffy Coat (cytology), Blood Buffy Coat (metabolism), Blood Buffy Coat (microbiology), Blood Platelets (cytology), Blood Platelets (metabolism), Blood Platelets (microbiology), Blood Proteins (metabolism), Female (MeSH), Furocoumarins (pharmacology), Humans (MeSH), Male (MeSH), Microbial Viability (drug effects), Photosensitizing Agents (pharmacology), Proteome (metabolism), Proteomics (MeSH), Sterilization (methods).
- MESH :
- chemical , metabolism : Blood Proteins, Proteome.
- cytology : Blood Buffy Coat, Blood Platelets.
- drug effects : Microbial Viability.
- metabolism : Blood Buffy Coat, Blood Platelets.
- methods : Sterilization.
- microbiology : Blood Buffy Coat, Blood Platelets.
- chemical , pharmacology : Furocoumarins, Photosensitizing Agents.
- Female, Humans, Male, Proteomics.
Abstract
In the past decades, transfusion medicine has been driven by the quest for increased safety against transfusion-transmitted infections, mainly by better donor selection and by the development of improved serological and nucleic-acid-based screening assays. Recently, pathogen reduction technologies became available and started to be implemented in several countries, with the primary goal to fight against bacterial contamination of blood products, a rare but dramatic event against which there was no definitive measure. Though pathogen reduction technologies represent a quantum leap in transfusion safety, the biomedical efficacy of platelet concentrates (PCs) treated with various pathogen reduction techniques has been recently questioned by clinical studies. Here, a gel-based proteomic analysis of PCs (n=5), Intercept-treated or untreated, from pooled buffy-coat (10 donors per PC) at Days 1, 2 and 8, shows that the Intercept process that is the most widespread pathogen reduction technique to date, has relatively low impact on the proteome of treated platelets: the process induces modifications of DJ-1 protein, glutaredoxin 5, and G(i)alpha 2 protein. As for the impact of storage, chloride intracellular channel protein 4 (CLIC4) and actin increased independently of Intercept treatment during storage. Whereas alteration of the DJ-1 protein and glutaredoxin 5 points out an oxidative stress-associated lesion, modification of G(i)alpha2 directly connects a possible Intercept-associated lesion to haemostatic properties of Intercept-treated platelets. This article is part of a Special Issue entitled: Integrated omics.
DOI: 10.1016/j.jprot.2012.07.008
PubMed: 22813878
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<term>Viabilité microbienne (effets des médicaments et des substances chimiques)</term>
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<front><div type="abstract" xml:lang="en">In the past decades, transfusion medicine has been driven by the quest for increased safety against transfusion-transmitted infections, mainly by better donor selection and by the development of improved serological and nucleic-acid-based screening assays. Recently, pathogen reduction technologies became available and started to be implemented in several countries, with the primary goal to fight against bacterial contamination of blood products, a rare but dramatic event against which there was no definitive measure. Though pathogen reduction technologies represent a quantum leap in transfusion safety, the biomedical efficacy of platelet concentrates (PCs) treated with various pathogen reduction techniques has been recently questioned by clinical studies. Here, a gel-based proteomic analysis of PCs (n=5), Intercept-treated or untreated, from pooled buffy-coat (10 donors per PC) at Days 1, 2 and 8, shows that the Intercept process that is the most widespread pathogen reduction technique to date, has relatively low impact on the proteome of treated platelets: the process induces modifications of DJ-1 protein, glutaredoxin 5, and G(i)alpha 2 protein. As for the impact of storage, chloride intracellular channel protein 4 (CLIC4) and actin increased independently of Intercept treatment during storage. Whereas alteration of the DJ-1 protein and glutaredoxin 5 points out an oxidative stress-associated lesion, modification of G(i)alpha2 directly connects a possible Intercept-associated lesion to haemostatic properties of Intercept-treated platelets. This article is part of a Special Issue entitled: Integrated omics.</div>
</front>
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